The tissue adhesive Histoacryl® consists of monomeric n-butyl-2-cyanoacrylate, which polymerises quickly in connection with tissue fluid. Histoacryl® is available in two colors: translucent, special for facial application, and blue, which enables an easy control over the quantity applied. The formation of esophageal and fundal varices is a common and dangerous consequence of portal hypertension. Effective sclerosation of these varices is possible with Histoacryl®. It can be employed for nonbleeding and for bleeding varices. Combined therapy with Histoacryl® and conventional sclerosation therapy is possible.